A spatially-averaged mathematical model of kidney branching morphogenesis
نویسندگان
چکیده
منابع مشابه
Branching morphogenesis and kidney disease.
Branching morphogenesis in the kidney is a tightly regulated, complex process and its disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary syndromes to common conditions such as hypertension and chronic kidney failure. This review synthesizes data on branching during kidney development derived from in vitro and in vivo rodent studies and to apply them to...
متن کاملDynamic Image-Based Modelling of Kidney Branching Morphogenesis
Kidney branching morphogenesis has been studied extensively, but the mechanism that defines the branch points is still elusive. Here we obtained a 2D movie of kidney branching morphogenesis in culture to test different models of branching morphogenesis with physiological growth dynamics. We carried out image segmentation and calculated the displacement fields between the frames. The models were...
متن کاملDevelopmental Programming of Branching Morphogenesis in the Kidney.
The kidney developmental program encodes the intricate branching and organization of approximately 1 million functional units (nephrons). Branching regulation is poorly understood, as is the source of a 10-fold variation in nephron number. Notably, low nephron count increases the risk for developing hypertension and renal failure. To better understand the source of this variation, we analyzed t...
متن کاملS08-02 Control of branching morphogenesis during kidney development
The anterior foregut of the mammalian embryo initially consists of a simple epithelial tube surrounded by undifferentiated mesoderm. As development proceeds this tube separates into two – the dorsal esophagus and the ventral trachea – while the primary lung buds at the distal end of the trachea undergo extensive branching morphogenesis to give rise to the lungs. The simple epithelium in each re...
متن کاملBranching morphogenesis.
Tubular structures are a fundamental anatomic theme recurring in a wide range of animal species. In mammals, tubulogenesis underscores the development of several systems and organs, including the vascular system, the lungs, and the kidneys. All tubular systems are hierarchical, branching into segments of gradually diminishing diameter. There are only 2 cell types that form the lumen of tubular ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2015
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2015.04.015